Antihistamines form the mainstay of therapy as they block the effect of histamine, and control the itching. Depending upon the severity and frequency of episodes, these anti-histamines may have to be continued for a long duration. Drowsiness is a common side-effect, however the newer generation antihistamines are less sedating.
If Urticaria does not respond to conventional antihistamines, other medicines like Montelukast or Oral steroids can be used.
Newer medicines i.e. Biologicals like Omalizumab are now available for treatment of resistant Autoimmune Urticaria.
In case of Angioedema causing breathing difficulty, adrenaline may have to be administered.